Francisella tularensis D-Ala D-Ala Carboxypeptidase DacD Is Involved in Intracellular Replication and It Is Necessary for Bacterial Cell Wall Integrity
نویسندگان
چکیده
Citation: Spidlova P, Stojkova P, Dankova V, Senitkova I, Santic M, Pinkas D, Philimonenko V and Stulik J (2018) Francisella tularensis D-Ala D-Ala Carboxypeptidase DacD Is Involved in Intracellular Replication and It Is Necessary for Bacterial Cell Wall Integrity. Front. Cell. Infect. Microbiol. 8:111. doi: 10.3389/fcimb.2018.00111 Francisella tularensis D-Ala D-Ala Carboxypeptidase DacD Is Involved in Intracellular Replication and It Is Necessary for Bacterial Cell Wall Integrity
منابع مشابه
A Method for Functional Trans-Complementation of Intracellular Francisella tularensis
Francisella tularensis is a highly infectious bacterial pathogen that invades and replicates within numerous host cell types. After uptake, F. tularensis bacteria escape the phagosome, replicate within the cytosol, and suppress cytokine responses. However, the mechanisms employed by F. tularensis to thrive within host cells are mostly unknown. Potential F. tularensis mutants involved in host-pa...
متن کاملDifferential Substrate Usage and Metabolic Fluxes in Francisella tularensis Subspecies holarctica and Francisella novicida
Francisella tularensis is an intracellular pathogen for many animals causing the infectious disease, tularemia. Whereas F. tularensis subsp. holarctica is highly pathogenic for humans, F. novicida is almost avirulent for humans, but virulent for mice. In order to compare metabolic fluxes between these strains, we performed 13C-labeling experiments with F. tularensis subsp. holarctica wild type ...
متن کاملStructural basis for the evolution of vancomycin resistance
Vancomycin resistance in Gram-positive bacteria is due to production of cell-wall precursors ending in D-Ala-D-Lac or D-Ala-D-Ser, to which vancomycin exhibits low binding affinities, and to the elimination of the high-affinity precursors ending in D-Ala-D-Ala. Depletion of the susceptible high-affinity precursors is catalyzed by the zinc-dependent D,D-peptidases VanX and VanY acting on dipepti...
متن کامل5-Aminolevulinic acid synthesis in epimastigotes of Trypanosoma cruzi.
BACKGROUND AND AIMS Trypanosoma cruzi is the causative agent of Chagas disease or American trypanosomiasis. The parasite manifests a nutritional requirement for heme compounds because of its biosynthesis deficiency. The aim of this study has been to investigate the presence of metabolites and enzymes of porphyrin pathway, as well as ALA formation in epimastigotes of T. cruzi, Tulahuén strain, T...
متن کاملThe Effect of Exercise Training Intensity and Alpha-Lipoic Acid Supplement on IAPP Gene Expression in the Pancreas in Type 2 Diabetic
Background: The formation of islet amyloid polypeptide (IAPP) have been proposed for d increased b-cell apoptosis in type 2 diabetes. Exercise training plays a protective role against diabetes. Alpha lipoic acid (ALA) is a powerful biological antioxidant. However, the role of exercise training and ALA on IAPP are not well understood. The aim of the present study was to investigate the effect of...
متن کامل